Activity of Carbazole, Aminoguanidine and Diamine Anti-infectives against <i>Toxoplasma gondii</i>.

ABSTRACT: We report the observation that carbazole anti-infectives developed as antibacterial and antifungal drug leads have activity against the tachyzoite-stage growth of the Apicomplexan parasite Toxoplasma gondii with IC₅₀ values as low as 2 μM. We show that a phenylthiazole aminoguanidine with antibacterial as well as antifungal activity inhibits growth with an IC₅₀ value of 2.1 μM. We also tested a series of 18 analogs of the diamine SQ109, a tuberculosis drug candidate which likewise has both antibacterial and antifungal activity, finding activity as low as 2.3 μM. We tested all compounds for their activity in collapsing the ΔpH component of the promotive force, the results indicating that all compounds acted, at least in part, as protonophore uncouplers. Finally,

SUBMITTER: Singh D 

PROVIDER: S-EPMC11844542 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature