Hematologic dynamics during pregnancy and their association with obstetric complications: a retrospective cohort study.

ABSTRACT:

Objectives

Pregnancy alters hematologic state as measured by complete blood counts (CBC), but the longitudinal changes in CBC indices that define healthy pregnancies are not well established. Our objectives were (1) to define gestational age-specific reference intervals for CBCs and their longitudinal changes in a large United States-based cohort and (2) to use these reference intervals to examine associations between extreme CBC values and changes and risk of obstetric complications.

Design

Retrospective cohort study including electronic health record-based discovery and validation cohorts.

Setting

Academic medical center and affiliated health system in the United States between 1998 and 2022.

Participants

Individuals with singleton pregnancies delivering afte

SUBMITTER: Tozzo V 

PROVIDER: S-EPMC11844592 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature