Variant-specific antibody correlates of protection against SARS-CoV-2 Omicron symptomatic overall infections.

ABSTRACT:

Background

Vaccination prior infection elicit neutralizing antibodies targeting SARS-CoV-2, yet the quantitative relationship between serum antibodies infection risk against viral variants remains uncertain, particularly in underrepresented regions.

Methods

We investigated the protective correlation of pre-exposure serum neutralizing antibody levels, employing a panel of SARS-CoV-2 pseudoviruses (Omicron BA.1, Omicron BA.2, ancestral D614G), Spike-binding antibody levels, with symptomatic BA.1 or BA.2 SARS-CoV-2 infections overall infection, in 345 household contacts from a SARS-CoV-2 household cohort study.

Results

A four-fold increase in homotypic-neutralizing (e.g., BA.1-neutralizing vs. BA.1 exposure) titers was correlated with protection from symptomatic infectio

SUBMITTER: Zambrana JV 

PROVIDER: S-EPMC11844606 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature