Plasma and neuroimaging biomarkers of small vessel disease and Alzheimer's disease in a diverse cohort: MESA.

ABSTRACT:

Introduction

Little is known about how Alzheimer's disease (AD) plasma biomarkers relate to cerebral small vessel disease (cSVD) neuroimaging biomarkers.

Methods

The study involved 251 Wake Forest Multi-Ethnic Study of Atherosclerosis (MESA) Exam 6 participants with plasma AD biomarkers, MRI, amyloid PET, and adjudicated cognitive status. Multivariable models examined cross-sectional relationships between plasma and neuroimaging biomarkers, considering comorbidities.

Results

Lower Aβ42/Aβ40, and higher GFAP, NfL, and p-tau217 were associated with greater neurodegeneration. Lower plasma Aβ42/Aβ40 and higher p-tau217 and p-tau231 were associated with greater Aβ PET deposition. NfL was positively associated with WMH and WM Free Water. P-tau measures were positively assoc

SUBMITTER: Lockhart SN 

PROVIDER: S-EPMC11844615 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature