Effects of Cacna1d D307G Mutation on Blood Pressure and Kidney Function in Rats with Salt Loading.

ABSTRACT:

Introduction

Our recent findings revealed that CACNA1D D307G mutation participates in the early-onset hypertension.

Methods

We used the CRISPR/Cas9 technique to generate the Cacna1d D307G mutation rat model and investigated the effects of Cacna1d D307G mutation on blood pressure (BP) and renal function. Rats fed normal-salt diet had normal plasma aldosterone levels but higher plasma ET-1 and mildly elevated systolic BP (SBP) in D307G and G307G rats compared with the wild type (WT) until 24 weeks. Renal function and renal histopathology did not significantly differ among the three groups.

Results

When fed high-salt diet (HSD), D307G and G307G rats showed more sensitivity to HSD. The results showed a further increase in SBP than in WT rats. Plasma and vascular endotheli

SUBMITTER: Cheng L 

PROVIDER: S-EPMC11844681 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature