KETO-MOOD: Ketogenic Diet for Microbiome Optimization and Overcoming Depression - A Protocol for a Randomized Controlled Trial.

ABSTRACT:

Introduction

Major depressive disorder (MDD) significantly impacts millions worldwide, with limited success in achieving remission for many patients, leading to high disease burden and increased suicide risk. Psychotherapy and antidepressants, although effective, do not provide relief for all, prompting the search for alternative treatments. Ketogenic diets have demonstrated positive effects on brain health. Our study aims to investigate the efficacy of the ketogenic diet in alleviating MDD symptoms, filling a critical gap in psychiatric treatment options and offering a novel dietary approach with potential to mitigate disease burden and enhance mental well-being.

Methods

This phase 2 randomized controlled trial will evaluate the efficacy of a 10-week program of dietitian co

SUBMITTER: Hongler K 

PROVIDER: S-EPMC11844705 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature