Metabolic pathways of Alternative Lengthening of Telomeres in pan-carcinoma.

ABSTRACT: Alternative Lengthening of Telomeres (ALT) is a telomerase-independent mechanism deployed by several aggressive cancers to maintain telomere length. This contributes to their malignancy and resistance to conventional therapies. In prior studies, we have identified key proteins linked to the ALT process using multi-omic data integration strategies. In this work, we combined metabolomic datasets with our earlier results to identify targetable metabolic pathways for ALT-positive tumors. 39 ALT-related proteins were found to interact with 42 different metabolites in our analysis. Additional networking analysis revealed a complex interaction between metabolites and ALT-related proteins, suggesting that pan-cancer oncogenes may have an impact on these pathways. Three metabolic pathways have been

SUBMITTER: Armendariz-Castillo I 

PROVIDER: S-EPMC11845024 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature