Comparative efficacy of different antihypertensive drug classes for stroke prevention: A network meta-analysis of randomized controlled trials.

ABSTRACT:

Objective

The study aimed to compare the effectiveness of various antihypertensive drugs in preventing strokes in hypertensive patients.

Methods

We conducted a comprehensive search of PubMed, Embase, the Cochrane Library, and ClinicalTrials.gov to identify randomized controlled trials (RCTs) investigating the efficacy of antihypertensive drugs in stroke prevention from inception until April 2023. A network meta-analysis in a Bayesian framework was performed using the random-effects model.

Results

This study included 88 RCTs involving 487,076 patients to investigate the effects of antihypertensive drugs in preventing stroke. Among these trials, 58 RCTs specifically focused on comparing the impact of such drugs on hypertensive subjects. In overall population, Angiotensi

SUBMITTER: Yu D 

PROVIDER: S-EPMC11845040 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature