Early sepsis recognition: a pilot study using a rapid high-multiplex host-response mRNA diagnostic test.

ABSTRACT:

Background

Early sepsis diagnosis is essential to allow timely initiation of adequate care. The TriVerity™ Test, performed on the Myrna™ Instrument, is the first rapid high-multiplex host-response mRNA diagnostic test that supports clinical decision-making by evaluating the likelihood of bacterial and/or viral infections and severity of illness. We present findings of the first, proof of concept, real-world evaluation in an emergency department (ED).

Methods

Blood was collected in PAXgene^® Blood RNA tubes from adult patients visiting the ED with suspicion of infection between 4th December 2023 and 22nd January 2024. TriVerity was performed within 1 h (RNA extraction and amplification of 29 host mRNAs using LAMP technology on the Myrna Instrument within approximate

SUBMITTER: Lu J 

PROVIDER: S-EPMC11845329 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature