Teicoplanin pharmacokinetics in critically ill patients on extracorporeal organ support: a retrospective analysis.

ABSTRACT:

Background

Extracorporeal membrane oxygenation (ECMO) can alter the pharmacokinetics of diverse antimicrobials, posing challenges in achieving therapeutic drug levels. Some literature suggests that teicoplanin may require higher dosing in ECMO patients, however the respective evidence is scarce. The aim of this study was to assess teicoplanin trough levels in critically patients on ECMO support and to compare patients with and without additional continuous renal replacement therapy (CRRT). We conducted a retrospective study at the Intensive Care Unit (ICU) of the University Hospital Zurich, Switzerland. Teicoplanin trough levels and doses were analyzed in critically ill patients during ECMO support by means of a non-parametric local estimated polynomial regression. Outcomes include

SUBMITTER: Camen G 

PROVIDER: S-EPMC11845331 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature