Glycomic profiling of parathyroid neoplasms via lectin microarray analysis.

ABSTRACT:

Purpose

Parathyroid carcinoma (PC) is a rare malignancy with a poor prognosis. Diagnosis of PC is often difficult in clinical practice and efficient diagnostic markers are still needed for differential diagnosis. Aberrant glycosylations of glycoproteins were identified with lectin microarray in various cancers, while relevant information is lacking in PC.

Methods

In this study, 8 PC and 6 parathyroid adenoma (PA) tissues were assessed using a microarray consisting of 70 lectins. Overall lectin-specific glycosylation patterns were compared between PA and PC tissues. Lectins with significant differential response between PC and PA were further validated by lectin histochemistry.

Results

The difference in signal intensities was found in 71.4% (50/70) of the lectins betwe

SUBMITTER: Zheng Q 

PROVIDER: S-EPMC11845408 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature