Long-Term Changes in Parameters of Bone Quality in Kidney Transplant Recipients Treated with Denosumab.

ABSTRACT: Kidney transplant recipients (KTRs) have an elevated fracture risk. While dual-energy X-ray absorptiometry (DXA) is commonly used to assess areal bone mineral density (aBMD), it does not capture all aspects of bone quality. We investigated the long-term effects on bone DXA-derived indices of bone quality in KTRs treated with denosumab and untreated with denosumab. This is a retrospective study, including KTRs treated with denosumab and untreated age and sex-matched KTR controls. DXA-derived parameters, including trabecular bone score (TBS) and 3D-DXA parameters, were measured at the lumbar spine and femur at baseline and after four years. Hierarchical linear models were used to assess the between-group effect of treatment over time, also adjusting for site-specific aBMDs. We enrolled 23 KT

SUBMITTER: Pollastri F 

PROVIDER: S-EPMC11845414 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature