Circulating metabolites of Borneolum syntheticum (Bingpian) ameliorate atherosclerosis in ApoE^-/- mice via inhibiting macrophage foam-cell formation.

ABSTRACT: Translational pharmacological research on traditional medicines lays the foundation for precisely understanding how the medicines function in the body to deliver therapeutic benefits. Borneolum syntheticum (Bingpian) is commonly used in Chinese herbal medicines for coronary heart disease, but its specific cardiovascular impact remains poorly understood. Isoborneol, a constituent of Bingpian, has been found to reduce lipid accumulation in macrophages in vitro, but its oral bioavailability is limited. This investigation aimed to evaluate anti-atherosclerotic effects of Bingpian, based on understanding its first-pass metabolism. Human subjects orally received an herbal medicine containing Bingpian and their plasma samples were analyzed to identify the major circulating compounds of Bingpian,

SUBMITTER: He RR 

PROVIDER: S-EPMC11845446 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature