Association between the use of proton pump inhibitors and serum PSA levels in the general U.S. population.

ABSTRACT:

Background

Proton pump inhibitors (PPIs) are widely prescribed drugs that have been associated with increased prostate cancer (PCa) cell proliferation in vitro and worse oncological outcomes in vivo. However, data on their influence on PSA levels in the general population are lacking.

Methods

We extracted individual participant data from the 2001-2010 cycles of the National Health and Nutrition Examination Survey (NHANES), in which PSA levels were measured in all male participants aged 40 years or older. The association of PPI use with total PSA levels and free/total PSA ratio was evaluated through multivariable linear regression analyses, adjusted for potential confounders.

Results

A total of 7366 subjects were included (median age: 53 years; median serum PSA: 0.9 ng

SUBMITTER: Bioletto F 

PROVIDER: S-EPMC11845559 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature