Shared genetic architecture and causal relationship between frailty and schizophrenia.

ABSTRACT: The complex relationship between frailty and schizophrenia has yet to be fully understood. This study aims to clarify their relationship by investigating their genetic links. We hypothesize a shared genetic architecture and a bidirectional causal relationship between the two conditions. Utilizing summary genetic data from European genome-wide association studies, we analyzed genetic associations through global and local correlations, shared genomic loci, tissue enrichments, and functional genes. Bidirectional Mendelian Randomization (MR) was employed to infer causality. Our findings show a positive genetic correlation between frailty and schizophrenia (LDSC: r_g = 0.117, p = 6.686 × 10^-7; HDL: r_g = 0.101, p = 5.63 × 10^-13) and local correlations i

SUBMITTER: Deng MG 

PROVIDER: S-EPMC11845589 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature