Independent and joint effects of genomic and exposomic loads for schizophrenia on psychotic experiences in adolescents of European ancestry.

ABSTRACT: This study aimed to assess the independent and joint associations of genomic and exposomic liabilities for schizophrenia with distressing psychotic experiences (PEs) and their persistence in early adolescence. The Adolescent Brain and Cognitive Development Study data from children with European ancestry were used (N = 5122). The primary outcome was past-month distressing PEs at the 3-year follow-up. Secondary outcomes were distressing PEs at varying cutoffs of persistence. Multilevel logistic regression models were used to test the associations of binary modes (>75th percentile) of polygenic risk score for schizophrenia (PRS-SCZ₇₅) and exposome score for schizophrenia (ES-SCZ₇₅) on the outcomes. Relative excess risk due to interaction (RERI) calculation indicated addi

SUBMITTER: Di Vincenzo M 

PROVIDER: S-EPMC11845623 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature