Causal relationship between circulating immune cells and the risk of esophageal cancer: a Mendelian randomization study.

ABSTRACT:

Background

Although relevant research has unveiled the intricate connections between immune cells and the occurrence and prognosis of esophageal cancer (EC), the specific impact of immune cell phenotypes on EC remains unclear.

Methods

We employed bidirectional two-sample Mendelian Randomization (MR) analysis to explore the causal relationship between immune cell phenotypes and EC. The summary data for immune cell phenotypes and EC are both sourced from the GWAS (Genome-Wide Association Study) database. Sensitivity analysis was conducted on the results, utilizing a combination of MR-Egger and MR-Presso to assess horizontal pleiotropy, employing Cochran's Q test to evaluate heterogeneity.

Results

We identified 24 immunophenotypes with potential causal relationships to E

SUBMITTER: Wang S 

PROVIDER: S-EPMC11845655 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature