Modelling the effects of climate change on the interaction between bacteria and phages with a temperature-dependent lifecycle switch.

ABSTRACT: Ongoing climate change and human activities alter the population dynamics of pathogenic bacteria in natural environments, increasing the risk of disease transmission. Among the key mechanisms of amplification of bacteria in the environment is the alteration of the natural control by their enemies, bacteriophages. Using mathematical modelling, we explore how climate change and implementation of certain agricultural practices affect interactions of bacteria with phage exhibiting condition-dependent lysogeny, where the type of phage infection lifecycle is determined by the ambient temperature. As a case study, we model alteration to the control of the pathogenic bacteria Burkholderia pseudomallei by its dominant phage. B. pseudomallei causes melioidosis, which is among the deadliest infection

SUBMITTER: Morozov A 

PROVIDER: S-EPMC11845662 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature