Perinatal obesity primes the hepatic metabolic stress response in the offspring across life span.

ABSTRACT: Perinatal obesity is associated with an increased risk of metabolic diseases and hepatic dysfunction in offspring. However, the underlying mechanisms of this metabolic programming remain incompletely understood. This study aimed to elucidate the influence of maternal obesity and early life exposure to high-fat diet on offspring liver phenotype, hepatokine profile, and key components of hepatic metabolism. To this end, we employed a murine high-fat diet-induced perinatal obesity model, investigating the offspring in early life and late adulthood. After exposure to perinatal obesity, the offspring showed a significantly increased body weight in early life with no histological signs of steatosis, but a dysregulated hepatokine profile. Proteomic profiling, followed by molecular analyses, revea

SUBMITTER: Stegmann SK 

PROVIDER: S-EPMC11845730 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature