TIMP4 serves as a novel potential prognostic biomarker for oral squamous cell carcinoma.

ABSTRACT: The abnormal expression of tissue inhibitor of metalloproteinase 4 (TIMP4) is associated with multiple human cancers. However, the role of TIMP4 in oral squamous cell carcinoma (OSCC) remains elusive. Therefore, this study explored the expression profile and prognosis of TIMP4 in OSCC. Tumor and adjacent non-tumor tissues were collected from OSCC patients, and protein expression of TIMP4 was detected through immunohistochemistry (IHC) and positive cell counting. Additionally, The Cancer Genome Atlas-Head and Neck Squamous Cell Carcinoma (TCGA-HNSCC) dataset was used to analyze TIMP4 expression further to determine its relationship with HNSCC clinical characteristics. Kaplan-Meier analysis was used to evaluate survival and prognosis. Meanwhile, the Tumor Immune Estimation Resource (TIMER) d

SUBMITTER: Zhou L 

PROVIDER: S-EPMC11845745 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature