Intestinal human carboxylesterase 2 (CES2) expression rescues drug metabolism and most metabolic syndrome phenotypes in global Ces2 cluster knockout mice.

ABSTRACT: Carboxylesterase 2 (CES2) is expressed mainly in liver and intestine, but most abundantly in intestine. It hydrolyzes carboxylester, thioester, and amide bonds in many exogenous and endogenous compounds, including lipids. CES2 therefore not only plays an important role in the metabolism of many (pro-)drugs, toxins and pesticides, directly influencing pharmacology and toxicology in humans, but it is also involved in energy homeostasis, affecting lipid and glucose metabolism. In this study we investigated the pharmacological and physiological functions of CES2. We constructed Ces2 cluster knockout mice lacking all eight Ces2 genes (Ces2^-/- strain) as well as humanized hepatic or intestinal CES2 transgenic strains in this Ces2^-/- background. We showed that oral availabil

SUBMITTER: Wang YG 

PROVIDER: S-EPMC11845761 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature