Potassium Release From the Habenular Astrocytes Induces Depressive-Like Behaviors in Mice.

ABSTRACT: The habenula has been implicated in psychiatric disorders such as depression, primarily because of its role in the modulation of the dopaminergic and serotonergic systems, which play a role in the pathophysiology of these disorders. Despite growing evidence supporting the role of the habenula in behavioral regulation, the process by which neural cells develop in the habenula remains elusive. Since the habenular anlage is found in the prosomere 2 domain expressing transcription factor Dbx1 in mouse embryos, we hypothesized that the Dbx1-expressing prosomere domain is a source of astrocytes that modulate neuronal activity in the habenula. To address this, we examined the cell lineage generated from Dbx1-expressing cells in male mice using tamoxifen-inducible Cre recombinase under the control

SUBMITTER: Aizawa H 

PROVIDER: S-EPMC11845841 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature