Epigenetic Clock Analysis for National Institutes of Health Stroke Scale in Patients With Ischemic Stroke.

ABSTRACT:

Aim

Strokes are the second most common cause of mortality and disability worldwide. Ischemic strokes account for the main part of strokes. Recently, the epigenetic changes that occur during biological aging through DNA methylation have gained attention. The National Institutes of Health Stroke Scale (NIHSS) scores measure physical and cognitive function. We hypothesized that there are associations between acute changes in the NIHSS score and biological aging in patients with ischemic stroke. We conducted epigenetic clock analyses to investigate the association between the difference in NIHSS (dNIHSS) and epigenetic clock in patients with ischemic stroke.

Methods

We used two publicly available DNA methylation data sets from Caucasian patients with ischemic stroke in Spain. Th

SUBMITTER: Jiang W 

PROVIDER: S-EPMC11845873 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature