The temporal requirements for insulin signaling during development in Drosophila.

ABSTRACT: Recent studies have indicated that the insulin-signaling pathway controls body and organ size in Drosophila, and most metazoans, by signaling nutritional conditions to the growing organs. The temporal requirements for insulin signaling during development are, however, unknown. Using a temperature-sensitive insulin receptor (Inr) mutation in Drosophila, we show that the developmental requirements for Inr activity are organ specific and vary in time. Early in development, before larvae reach the "critical size" (the size at which they commit to metamorphosis and can complete development without further feeding), Inr activity influences total development time but not final body and organ size. After critical size, Inr activity no longer affects total development time but does influence final

SUBMITTER: Shingleton AW 

PROVIDER: S-EPMC1184592 | biostudies-literature | 2005 Sep

REPOSITORIES: biostudies-literature