Therapeutic Potential of Extracellular Vesicles (Exosomes) Derived From Platelet-Rich Plasma: A Literature Review.

ABSTRACT:

Background

There are exciting advances in the field of exosomes research as a potential regenerative therapy. Platelet-rich plasma represents an abundant source of exosomes.

Aim

To present evidence on the use of platelet-rich plasma-derived exosomes in dermatology and discuss current technical limitations.

Methods

A literature search was conducted using Embase (Ovid), Web of Science, and ClinicalTrials.gov in June 2024.

Results

Platelet-rich plasma-derived exosomes contain a myriad of growth factors, genetic materials, and lipids that mediate paracrine signaling. Several preclinical studies have demonstrated their potential in wound healing. This includes faster wound contraction in diabetic animal models, as well as enhanced angiogenesis, increased cell prolif

SUBMITTER: Gupta AK 

PROVIDER: S-EPMC11845942 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature