Skin Microbiota and Pathological Scars: A Bidirectional Two-Sample Mendelian Randomization Study.

ABSTRACT:

Background

Pathological scars (PSs), resulting from abnormal skin repair, chronic inflammation, and fibrosis, affect millions of people. Previous studies have demonstrated that skin microbiota (SM) plays a role in cutaneous inflammation and healing, but the interplay between PSs and SM remains unclear yet.

Objective

To investigate the causal associations between SM and two specific PSs: hypertrophic scars (HSs) and keloids.

Methods

A bidirectional two-sample mendelian randomization (MR) analysis using genetic data for SM, HS, and keloids was conducted. The random-effects inverse variance weighted (IVW) method was used as the primary approach, along with multiple MR methods. False discovery rate (FDR) correction was employed to address multiple testing.

Results

SUBMITTER: Huang Y 

PROVIDER: S-EPMC11845961 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature