Evaluation of the In Vivo Skin Penetration of TXVector by Confocal Raman Spectroscopy.

ABSTRACT:

Background

Tranexamic acid (TXA) is a promising active to treat hyperpigmentation disorders, such as melasma and acne scars. However, TXA is highly hydrophilic and its penetration into the skin is poor and formulation dependent.

Aims

In this study, our aim was to evaluate the in vivo skin penetration of an ester-modified TXA, TXVector, directly on the skin of volunteers.

Methods

For the analysis of in vivo skin penetration of TXVector, we used in vivo confocal Raman spectroscopy (CRS). The use of CRS on live skin allows us to study directly how a compound affects skin composition at different depths and how this compound penetrates into the skin in real time.

Results

Our results showed that the TXA absorption into the skin via TXVector was 2.1-fold and 3.8-fold

SUBMITTER: Winn D 

PROVIDER: S-EPMC11845972 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature