Kidney function decline improves after lithium discontinuation.

ABSTRACT:

Background

Long-term lithium treatment decreases kidney function. However, it remains unclear whether stopping lithium improves kidney function.

Objectives

To study kidney function in patients who stopped and subsequently restarted lithium treatment.

Methods

Mirror-image design using data from the LiSIE retrospective cohort study. The mirror was set to when lithium was stopped with a 5-year pre- and post-mirror period. Adult patients with bipolar, schizoaffective disorder or unipolar depression, who had lithium ≥4.5 years in the pre-mirror period, were included. Creatinine measurements were available from 1997 to 2017. The main outcome was the difference in mean annual change of the estimated glomerular filtration rate (eGFR) adjusted for sex, hypertension and diabete

SUBMITTER: Fransson F 

PROVIDER: S-EPMC11846072 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature