Correcting <i>SUVR</i> bias by accounting for radiotracer clearance in tissue: A validation study with [¹⁸F]FE-PE2I PET in cross-sectional, test-retest and longitudinal cohorts.

ABSTRACT: Quantification of dopamine transporter (DAT) with [¹⁸F]FE-PE2I PET is an important progression marker for Parkinson's disease (PD). This study aimed to validate a novel correction (SUVRc) for a less-biased estimate of SUVR by accounting for [¹⁸F]FE-PE2I clearance-rate, in independent cross-sectional (38 PD, 38 controls), test-retest (9 PD) and longitudinal cohorts (21 PD). SUVRc was calculated as SUVR1 - βrefk2,ref +βtarSUVRk2,refR1. β_tar and β_ref are the clearance rates from the target and reference tissues. Bias relative to DVR, discriminative power, test-retest variability (TRV) and annual longitudinal change (ALC) were used to compare SUVR_50-80 min, SUVRc_50-80 min,

SUBMITTER: Oh M 

PROVIDER: S-EPMC11846093 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature