Persistent impact of antenatal maternal anaemia on child brain structure at 6-7 years of age: a South African child health study.

ABSTRACT:

Background

This study aimed to determine whether associations of antenatal maternal anaemia with smaller corpus callosum, caudate nucleus, and putamen volumes previously described in children at age 2-3 years persisted to age 6-7 years in the Drakenstein Child Health Study (DCHS).

Methods

This neuroimaging sub-study was nested within the DCHS, a South African population-based birth cohort. Pregnant women were enrolled (2012-2015) and mother-child dyads were followed prospectively. A sub-group of children had magnetic resonance imaging at 6-7 years of age (2018-2022). Mothers had haemoglobin measurements during pregnancy and a proportion of children were tested postnatally. Maternal anaemia (haemoglobin < 11 g/dL) and child anaemia were classified using WHO and local guidelin

SUBMITTER: Ringshaw JE 

PROVIDER: S-EPMC11846184 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature