TAM-derived exosomal miR-589-3p accelerates ovarian cancer progression through BCL2L13.

ABSTRACT:

Background

Tumor-associated macrophages (TAM) are critical elements of intercellular communication in tumor microenvironment (TME), and exosomes are key mediators between tumor cells and the TME. According to previous reports, miRNAs exert a pivotal role in ovarian cancer (OC) development. The purpose of this work was to explore the function of TAM-derived exosomal miR-589-3p in OC development and elucidate the underlying molecular mechanisms.

Methods

First, peripheral blood mononuclear cells (PBMC) were treated with IL-4 and IL-13 to polarize them into M2-type macrophages. Exosomes were separated from M2-type macrophages, and the physical properties of exosomes were evaluated using transmission electron microscopy (TEM) and nanoparticle tracking analysis (NTA). Next, quanti

SUBMITTER: Wang J 

PROVIDER: S-EPMC11846191 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature