Single-round performance of colorectal cancer screening programs: a network meta-analysis of randomized clinical trials.

ABSTRACT:

Background

Demonstrating mortality reduction in new colorectal cancer (CRC) screening programs through randomized clinical trials (RCTs) is challenging. We systematically reviewed single-round program performance outcomes using a stepwise approach proposed by the World Endoscopy Organization CRC Screening Committee framework.

Methods

The MEDLINE, EMBASE, Central, and Ichushi Web databases were searched until October 28, 2024, to find RCTs comparing guaiac-based and immunochemical fecal occult blood testing (gFOBT and FIT), flexible sigmoidoscopy (FS), computed tomographic colonography (CTC), and total colonoscopy (TCS). Paired reviewers screened studies, extracted data, and assessed bias risk. A Bayesian random-effects network meta-analysis was conducted, and the certainty o

SUBMITTER: Terasawa T 

PROVIDER: S-EPMC11846209 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature