Identification of subtypes and biomarkers associated with disulfidptosis-related ferroptosis in ulcerative colitis.

ABSTRACT:

Background

Disulfidptosis and ferroptosis are different programmed cell death modes, which are closely related to the development of a variety of diseases, but the relationship between them and ulcerative colitis (UC) is still unclear. Therefore, our study aimed to explore the molecular subtypes and biomarkers associated with disulfidptosis-related ferroptosis (DRF) in UC.

Methods

We used Pearson analysis to identify DRF genes. Then, we classified 140 UC samples into different subtypes based on the DRF genes and explored the biological and clinical characteristics between them. Next, the hub genes were identified by differential analysis and WGCNA algorithms, and three machine learning algorithms were used to screen biomarkers for UC from hub genes. In addition, we analyzed

SUBMITTER: Jiang Y 

PROVIDER: S-EPMC11846262 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature