Camel milk exosomes regulate glucose metabolism by inhibiting mitochondrial complex I in hepatocytes.

ABSTRACT:

Background

Camel milk is known to have hypoglycemic properties. Previous studies found that camel milk exosomes (CM-exo) may regulate cellular glucose metabolism through the inhibition of mitochondrial complex I, but this hypothesis has not been verified by other experiments. The objective of this study was to verify the hypothesis that CM-exo regulated glucose metabolism in hepatocytes by inhibiting mitochondrial complex I pathway. AML12 cells were treated with extracted exosomes from camel milk and the effect of the CM-exo on cell viability was examined by cell counting kit (CCK)-8 assays. The glucose content of the cell culture medium was measured to determine the glucose consumption of the cells. Lactate release from the cells was determined by measuring the lactate content in

SUBMITTER: Yang B 

PROVIDER: S-EPMC11846279 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature