Monocytic myeloid-derived suppressor cells contribute to the exacerbation of bone destruction in periodontitis.

ABSTRACT:

Background

Periodontitis (PD) is a chronic infectious and inflammatory disease characterized by alveolar bone loss. The distinctive activity of immune cells critically exacerbates bone resorption in PD. Myeloid-derived suppressor cells (MDSCs) are known to contribute to various chronic inflammatory conditions, but their role in the pathogenesis and progression of PD remains poorly understood.

Methods

We used single-cell transcriptomic analysis with human gingival samples and animal models of experimental periodontitis to examine the role of M-MDSCs in PD. We also explored the therapeutic effect of depleting MDSCs on PD in vivo. Additionally, the mechanisms of long non-coding RNA Neat1 and the pathway of NF-κB-dependent "canonical NLRP3 inflammasome activation" in MDSCs were

SUBMITTER: Zhou Z 

PROVIDER: S-EPMC11846281 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature