Association between levothyroxine supplementation for hypothyroidism in late pregnancy and risk of prematurity: a population-based cohort study.

ABSTRACT:

Background

Hypothyroidism in pregnancy is associated with obstetrical and fetal complications, such as prematurity. However, whether its management by levothyroxine affects the risk of prematurity is not yet clear.

Methods

We conducted a cohort study within the Quebec Pregnancy Cohort including pregnancies with hypothyroidism from January 1, 1998, through December 31, 2015. In primary analyses, we considered levothyroxine exposure (yes/no), total duration, mean daily dose, and cumulative dose in the 2-months period before delivery (for preterm deliveries) or before 37th weeks' gestation (for term deliveries). Secondly, levothyroxine dosage before and after the beginning of the second trimester were compared, and pregnancies were categorized in increased or constant dosage gr

SUBMITTER: Laham M 

PROVIDER: S-EPMC11846315 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature