Systematic review on the DNA methylation role in endometriosis: current evidence and perspectives.

ABSTRACT:

Background

Endometriosis appears to have a multilayered etiology, with genetic and epigenetic factors each contributing half of the pathogenesis. The molecular processes that underlie the onset of endometriosis are yet unclear, but it is assumed that an important contributor in the etiopathology of the disease is DNA methylation.

Methods

We conducted a systematic review of the literature regarding DNA methylation in endometriosis following PRISMA guidelines. Records were obtained from PubMed and Web of Science on May 31, 2024. Original research articles analyzing regional or genome-wide DNA methylation in patients with confirmed endometriosis (by surgery and/or histological examination) were given consideration for inclusion. Only human studies were included, and there were

SUBMITTER: Ducreux B 

PROVIDER: S-EPMC11846336 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature