The microRNA landscape and regulatory network in Clonorchis sinensis-infected hepatocellular carcinoma: implications for tumor progression.

ABSTRACT:

Background

Hepatocellular carcinoma (HCC) is a leading cause of cancer mortality globally, and its progression is associated with various factors, including parasitic infections such as Clonorchis sinensis (C. sinensis). Although C. sinensis infection has been implicated in HCC, the molecular mechanisms, particularly the role of microRNAs (miRNAs), remain poorly understood. This study aims to fill this gap by investigating the miRNA expression profiles in C. sinensis⁺ and C. sinensis^- HCC tissues.

Method

We performed miRNA sequencing on HCC tissues from C. sinensis⁺ and C. sinensis^- patients, followed by bioinformatics analyses to identify differentially expressed miRNAs (DEMs) and their target genes. Gene Ontology (GO) enrichment

SUBMITTER: Wei C 

PROVIDER: S-EPMC11846337 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature