SPICE1 promotes osteosarcoma growth by enhancing the deubiquitination of FASN mediated by USP10.

ABSTRACT:

Background

Osteosarcoma (OS) is recognized as a prevalent primary bone malignancy, particularly affecting adolescents during their growth spurts. Despite its clinical significance, the underlying biological characteristics and associated prognostic factors remain incompletely understood. The identification of novel molecular players involved in osteosarcoma progression could enhance our understanding of its pathogenesis and potentially inform patient management strategies.

Methods

In this study, we investigated the expression levels of Spindle and Centriole-Associated Protein 1 (SPICE1) in OS cells and tissues through quantitative analyses. We performed in vitro and in vivo experiments to evaluate the proliferation effects of SPICE1 on OS cells. Additionally, we explored the

SUBMITTER: Tong W 

PROVIDER: S-EPMC11846344 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature