Investigating intestinal epithelium metabolic dysfunction in celiac disease using personalized genome-scale models.

ABSTRACT:

Background

Celiac disease (CeD) is an autoimmune condition characterized by an aberrant immune response triggered by the ingestion of gluten, which damages epithelial cells lining the small intestine. Small intestinal epithelial cells (sIECs) play key roles in the enzymatic digestion and absorption of nutrients, maintaining gut barrier integrity, and regulating immune response. Chronic inflammation and tissue damage associated with CeD disrupt the intricate network of metabolic processes in sIECs that support these functions, impairing their ability to perform their essential roles. However, the specific disrupted metabolic processes underlying sIECs dysfunction in CeD remain largely undefined.

Methods

To address this knowledge gap, personalized, sex-specific genome-scale mo

SUBMITTER: McCreery CV 

PROVIDER: S-EPMC11846356 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature