A pan-cancer analysis of the oncogenic and immunological roles of RGS5 in clear cell renal cell carcinomas based on in vitro experiment validation.

ABSTRACT:

Background

RGS5, the first gene identified in tumor-resident pericytes, plays a crucial role in angiogenesis. However, its effects on immunology and prognosis in human cancer are still mostly unknown. This study investigates the carcinogenic and immunological roles of RGS5 through a comprehensive pan-cancer analysis.

Methods

A standardized pan-cancer dataset for RGS5 was obtained from the public database. R software and relevant packages were utilized to analyze the oncogenic and immunological roles. Clinical samples and cellular experiments were conducted to validate RGS5 expression and its biological function in renal cancer.

Results

Bioinformatics analysis revealed that RGS5 is dysregulated in a variety of human malignancies and is significantly associated with pat

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC11846387 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature