Exposure of A2E to blue light promotes ferroptosis in the retinal pigment epithelium.

ABSTRACT:

Background

Age-dependent accumulation of lipofuscin in the retinal pigment epithelium (RPE) is closely related to the etiology of autosomal recessive Stargardt's disease (STGD1) and dry age-related macular degeneration (AMD). N-retinylidene-N-retinylethanolamine (A2E) is a leading component of RPE lipofuscin that is highly susceptible to blue light. Ferroptosis is an iron-dependent form of non-apoptotic cell death characterized by the accumulation of lipid peroxides to a lethal level, which plays an important role in retinal diseases. However, it remains unknown whether A2E functions as a physiological trigger for eliciting blue light-induced ferroptosis of RPE cells.

Methods

A2E-loaded RPE cells and Abca4^-/-Rdh8^-/- mice were exposed to blue light, resp

SUBMITTER: Yang B 

PROVIDER: S-EPMC11846388 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature