Disulfidptosis classification of pancreatic carcinoma reveals correlation with clinical prognosis and immune profile.

ABSTRACT:

Background

Disulfidptosis, a novel form of metabolism-related regulated cell death, is a promising intervention for cancer therapeutic intervention. Although aberrant expression of long-chain noncoding RNAs (lncRNAs) expression has been associated with pancreatic carcinoma (PC) development, the biological properties and prognostic potential of disulfidptosis-related lncRNAs (DRLs) remain unclear.

Methods

We obtained RNA-seq data, clinical data, and genomic mutations of PC from the TCGA database, and then determined DRLs. We developed a risk score model and analyzed the role of risk score in the predictive ability, immune cell infiltration, immunotherapy response, and drug sensitivity.

Results

We finally established a prognostic model including three DRLs (AP005233.2,

SUBMITTER: Shi J 

PROVIDER: S-EPMC11846472 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature