Specific contribution of cognitive and motor impairments with functional capacity and dependence in Huntington's disease.

ABSTRACT:

Background

Huntington's disease (HD) leads to increasing dependence. Unlike psychiatric disorders, motor and cognitive deficits evolve progressively over time. Understanding their specific impact on daily activities is crucial for preserving autonomy. However, because cognitive tasks in HD rely on motor functions, and motor tasks demand cognitive processing, disentangling their specific impact remains a challenge.

Objective

To identify the specific contribution of cognitive and motor impairments on global functional capacity, basic and instrumental activities of daily living (ADL/IADL), and work-related activities (WRA) in HD.

Methods

158 HD mutation carriers, enrolled in the BioHD (NCT01412125) and RepairHD (NCT03119246) studies, were evaluated with the Unified Hunti

SUBMITTER: Gil-Salcedo A 

PROVIDER: S-EPMC11846732 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature