Renal mitochondria response to sepsis: a sequential biopsy evaluation of experimental porcine model.

ABSTRACT:

Background

The pathophysiology of sepsis-induced acute kidney injury remains elusive. Although mitochondrial dysfunction is often perceived as the main culprit, data from preclinical models yielded conflicting results so far. The aim of this study was to assess the immune-metabolic background of sepsis-associated renal dysfunction using sequential biopsy approach with mitochondria function evaluation in a large clinically relevant porcine models mimicking two different paces and severity of sepsis and couple this approach with traditional parameters of renal physiology.

Methods

In this randomized, open-label study, 15 anaesthetized, mechanically ventilated and instrumented (renal artery flow probe and renal vein catheter) pigs were randomized in two disease severity groups-l

SUBMITTER: Muller J 

PROVIDER: S-EPMC11846788 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature