NR4A1 deficiency promotes carotid plaque vulnerability by activating integrated stress response via targeting Bcat1.

ABSTRACT: Rupture of vulnerable carotid atherosclerotic plaque is one of the leading causes of ischemic stroke. However, the mechanisms driving the transition from stable to vulnerable plaques have not yet been elucidated. NR4A1 is an orphan nuclear receptor that functions in various inflammatory diseases. To explore the role of NR4A1 in vulnerable plaque formation, we generated a vulnerable plaque mouse model by combining partial ligation of the left common carotid artery and left renal artery in ApoE^-/- and ApoE^-/-;NR4A1^-/- mice. Our research revealed that NR4A1 deficiency significantly worsened the pathology of vulnerable plaque, increasing intraplaque hemorrhage, rupture with thrombus, and the occurrence of multilayer with discontinuity. Moreover, NR4A1 deficienc

SUBMITTER: Chen L 

PROVIDER: S-EPMC11846829 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature