Controllability of nonlinear epileptic-seizure spreading dynamics in large-scale subject-specific brain networks.

ABSTRACT: Closed-loop electrical stimulation has become an important alternative to resective surgery for control of pharmacologically-resistant focal epileptic seizures. Seizure spread across large-scale brain networks, rather than its focal onset, is what commonly leads to major disruptions in sensorimotor and cognitive processing, as well as loss-of-consciousness, one of the main impairing aspects of the disorder. Electrical stimulation, triggered by early detection of seizure onset in epileptogenic zones (EZs), has been applied to prevent spread and its subsequent effects. Here, we show how linear feedback seizure-spread controllability in subject-specific (white-matter tractography) Epileptor network models is affected by variations in brain excitability, network coupling strength, control late

SUBMITTER: Moosavi SA 

PROVIDER: S-EPMC11846898 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature