Stage-dependent spatial distribution and prognostic value of CD8⁺ tissue-resident memory T cells in NSCLC.

ABSTRACT: CD8⁺ tissue-resident memory T cells (CD8⁺T_RM), expressing PD-1 and/or TIM-3, are linked to immunological surveillance in non-small cell lung cancer (NSCLC). However, their prognostic value across activation states and spatial distributions in NSCLC stages is unclear. We analyzed 271 NSCLC patients' primary tumors and lymph nodes, using multiplex immunohistochemistry and inForm software for cell identification. Statistical analyses included the Mann-Whitney U test and Cox survival analysis. Findings showed CD8⁺T_RM were categorized into four activation states. In locally advanced NSCLC, PD-1^-TIM-3⁺CD8⁺T_RM3, and PD-1⁺TIM-3⁺CD8⁺T_RM4 densities were notab

SUBMITTER: Yang L 

PROVIDER: S-EPMC11846915 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature