Multiple respiratory assessment and thresholds for noninvasive ventilation in adult patients with spinal muscular atrophy.

ABSTRACT: This study aimed to examine feasibility of inspiratory muscle strength tests, such as maximal inspiratory pressure (MIP) and sniff nasal inspiratory pressure (SNIP) in adult patients affected by spinal muscular atrophy (SMA), as well as their ability, along with forced vital capacity (FVC), to predict noninvasive ventilation (NIV) needs. Additionally, we evaluated feasibility and effectiveness of respiratory oscillometric measurements in the same patients. Twenty patients were retrospectively evaluated. NIV requirement was considered as peak nocturnal transcutaneous PCO₂ > 49 mmHg, according to the cut-off used by Ward et al. MIP and SNIP were feasible in all patients. SNIP had significantly higher values (p < 0.001) and poorly agreed with MIP. ROC analysis revealed MIP as a wea

SUBMITTER: Crescimanno G 

PROVIDER: S-EPMC11846990 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature