Accuracy-dependent dose-constraints and dose-based safety margins for organs-at-risk in radiotherapy.

ABSTRACT:

Background and purpose

Geometrical uncertainties in radiotherapy are generally accounted for by margins for tumors, but their effect on organs-at-risk (OARs) is often ignored. We developed a model that incorporates dose- and geometry-based uncertainties in OAR planning using dose constraints.

Materials and methods

Radiotherapy uncertainties cause real dose-volume histograms (DVHs) to spread around the planned DVH. With a published OAR dose constraint D(V_crit) < D_crit such that complication probability < Y%, real differences from planned D_crit can be described by mean- (MD_Dcrit) and standard deviations (SD_Dcrit). Assuming complications are associated with the worst DVHs, New dose constraints that maintain co

SUBMITTER: Stroom JC 

PROVIDER: S-EPMC11847229 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature